Exosome storage stability has long posed a significant challenge in exosome research. Typically, exosomes are stored in PBS at -80°C; however, prolonged storage and repeated freeze-thaw cycles can lead to substantial degradation of their activity, structural integrity, and cargo content. To overcome this issue, a specialized exosome cryopreservation solution has been developed. When mixed directly with exosome samples and stored at temperatures ranging from -5°C to -20°C or -80°C, this solution significantly enhances both short-term and long-term stability. The product is distinguished by its user-friendly application, effective protective properties, well-defined chemical composition, and versatility across various sample types. Furthermore, it effectively prevents exosome adsorption to experimental consumables such as sample tubes and pipette tips, ensuring minimal loss and maximizing recovery.