Amphotericin B, also known as Lushanmycin, is a polyene antifungal antibiotic isolated from the culture supernatant of Streptomycesnodosus. Its antibacterial mechanism it can combine with ergosterol on the membrane of the fungus, resulting in cell membrane damage, the permeability is improved, thematerial inside the cell are leakaged, which disrupts normal metabolism and plays a bacteriostatic effect. Bacteria are ineffective because they do not contain ergosterol on their cell membranes. Amphotericin B has a broad antifungal spectrum, is effective against almost all fungi, and resistant strains are rare. It exhibits bactericidal effect at high concentrations. The amphotericin B solution is unstable at room temperature, easily damaged by light, heat and acid, and has the strongest antibacterial effect at pH 6.0-7.5.
Matters Need Attention
1. This product is for research use only.
2. This product is sterilized by 0.1μm filtration.
3. It is necessary to pay attention to the aseptic operation and avoid the pollution.
4. It is not suitable for long time storage at room temperature or 4 °C.
5. Thaw in 2 -8°C and mix fully before use.Avoid repeated freezing and thawing. It is recommended to aliquot the solution and store at -20°C.
6. This product is a concentrated solution and dilute it to the desired concentration before use.
